Mice with a specific genetic modification that causes heart failure had about 30% worse heart pumping ability compared to normal mice.
Scientific Claim
Cardiac-specific MST-1 overexpression in mice resulted in 29% lower ejection fraction and 38% lower fractional shortening compared to wild-type mice.
Original Statement
“Ejection fraction and fractional shortening were 29% and 38% less, respectively, in MST‐1 mice receiving saline compared to WT mice receiving saline (P < 0.01; Table 2)”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The claim correctly describes the comparison between mouse groups without implying causation beyond the study design. It specifies the model and measurement method.
More Accurate Statement
“Cardiac-specific MST-1 overexpression in mice was associated with 29% lower ejection fraction and 38% lower fractional shortening compared to wild-type mice.”
Evidence from Studies
Supporting (1)
N‐acetylcysteine attenuates the development of cardiac fibrosis and remodeling in a mouse model of heart failure