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Back to Study: The homeoviscous adaptation to dietary lipids (HAD...
correlational
Analysis v1
Strong Support

High LDL cholesterol might not always lead to heart disease if a person is metabolically healthy — it could depend on whether they have insulin resistance or other metabolic issues.

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Evidence from Studies

Supporting (1)

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The homeoviscous adaptation to dietary lipids (HADL) model explains controversies over saturated fat, cholesterol, and cardiovascular disease risk.

Narrative Review
2021 Feb 2

The study says that higher LDL cholesterol from eating certain fats might be the body's normal way of adjusting, not a sign of disease, especially if a person is metabolically healthy.

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

The homeoviscous adaptation to dietary lipids (HADL) model explains controversies over saturated fat, cholesterol, and cardiovascular disease risk.

Score: 1
DOI: 10.1093/ajcn/nqaa322

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