A lot of people with heart problems don't actually have high LDL cholesterol — about half of them have normal or even low levels — so maybe LDL isn't the main cause of heart disease after all.

Pro

Against

Evidence from Studies

Supporting (2)

Community contributions welcome

Is Targeting LDL-C Levels Below 70 mg/dL Beneficial for Cardiovascular and Overall Health? A Critical Examination of the Evidence

Narrative Review

2025 May 20

Untitled Study

Contradicting (2)

Community contributions welcome

Low-Density Lipoprotein Cholesterol Is Predominantly Associated With Atherosclerotic Cardiovascular Disease Events in Patients With Evidence of Coronary Atherosclerosis: The Western Denmark Heart Registry

Cohort Study

Human

2023 Apr 4

The LDL cumulative exposure hypothesis: evidence and practical applications

Narrative Review

2024 Oct

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

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