How long a girl takes a certain puberty-delaying medicine doesn’t change when her period starts after she stops the treatment — her body picks up where it left off, no matter how long she was on the drug.

For girls who get early puberty and are treated with certain hormone shots, their first period usually comes about a year after stopping treatment — most within one to two years — so doctors can expect when things will start up again.

For girls with early puberty, stopping either leuprolide or histrelin leads to periods starting again at about the same pace — so both treatments seem to wear off in a similar way.

If a girl's bones mature faster while she's on treatment for early puberty, she's likely to start her period sooner after stopping the medicine — even if we account for how mature her bones were to begin with.

Girls with early puberty who start treatment with certain hormone drugs tend to get their first period sooner after stopping treatment if their bones are more mature when they begin the therapy.

Girls with early puberty who are further along in breast development when they start a certain treatment tend to get their first period sooner after stopping the treatment compared to girls who were less developed when they started.