For girls with early puberty, stopping either leuprolide or histrelin leads to periods starting again at about the same pace — so both treatments seem to wear off in a similar way.

39

Pro

0

Against

Evidence from Studies

Supporting (1)

39

Community contributions welcome

39

Clinical findings influencing time to menarche post gonadotropin-releasing hormone agonist therapy in central precocious puberty

Cohort Study

Human

2021 Sep

The study looked at when girls got their first period after stopping two different medicines (leuprolide and histrelin) used for early puberty. It found the timing was similar no matter which medicine was used, supporting the idea that both work the same way after stopping.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Clinical findings influencing time to menarche post gonadotropin-releasing hormone agonist therapy in central precocious puberty

Score: 39

DOI: 10.6065/apem.2040220.110

Similar Assertions

How long a girl takes a certain puberty-delaying medicine doesn’t change when her period starts after she stops the treatment — her body picks up where it left off, no matter how long she was on the drug.

39

0

86%

For girls who get early puberty and are treated with certain hormone shots, their first period usually comes about a year after stopping treatment — most within one to two years — so doctors can expect when things will start up again.

39

0

83%

If a girl's bones mature faster while she's on treatment for early puberty, she's likely to start her period sooner after stopping the medicine — even if we account for how mature her bones were to begin with.

39

0

76%