When will periods start after stopping puberty-pausing medicine?
Clinical findings influencing time to menarche post gonadotropin-releasing hormone agonist therapy in central precocious puberty
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Treatment duration had no effect on time to menarche.
Many assume longer treatment = longer delay in puberty, but the body seems to reactivate puberty based on biological readiness, not how long it was paused.
Practical Takeaways
Doctors can use breast stage and bone age at treatment start to estimate when puberty will restart after stopping medication.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Treatment duration had no effect on time to menarche.
Many assume longer treatment = longer delay in puberty, but the body seems to reactivate puberty based on biological readiness, not how long it was paused.
Practical Takeaways
Doctors can use breast stage and bone age at treatment start to estimate when puberty will restart after stopping medication.
Publication
Journal
Annals of Pediatric Endocrinology & Metabolism
Year
2021
Authors
V. Wu, Victoria Zhao, Rula Issa, Meredith Wilkes, E. Wallach, R. Rapaport, C. Romero, M. Yau
Related Content
Claims (7)
For girls with early puberty, stopping either leuprolide or histrelin leads to periods starting again at about the same pace — so both treatments seem to wear off in a similar way.
Girls with early puberty who start treatment with certain hormone drugs tend to get their first period sooner after stopping treatment if their bones are more mature when they begin the therapy.
How long a girl takes a certain puberty-delaying medicine doesn’t change when her period starts after she stops the treatment — her body picks up where it left off, no matter how long she was on the drug.
For girls who get early puberty and are treated with certain hormone shots, their first period usually comes about a year after stopping treatment — most within one to two years — so doctors can expect when things will start up again.
Girls with early puberty who are further along in breast development when they start a certain treatment tend to get their first period sooner after stopping the treatment compared to girls who were less developed when they started.