When will periods start after stopping puberty-pausing medicine?
Clinical findings influencing time to menarche post gonadotropin-releasing hormone agonist therapy in central precocious puberty
doi:10.6065/apem.2040220.110Lower Quality
Methodology score · 39/100
We translate health research into clear, actionable insights. Here’s what this study found and what it means for you.
Not medical advice. For informational purposes only. Always consult a healthcare professional.
This study looked back at medical records of 39 girls who had early puberty and were treated with hormone medicine. It found that girls who were further along in puberty when treatment started got their first period sooner after stopping the medicine. But it can't say for sure that being further along caused this — just that these things happened together.
What’s the bottom line?
This study looked at when girls get their first period after stopping medicine that pauses early puberty.
Where does this study sit?
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 539 / 72
Evidence Score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Key takeaways
Pre-validation
Based on the study abstract and findings — summarized and made actionable before scientific validation.
- 1Knowing when puberty will restart helps families and doctors plan ahead for physical and emotional changes.
- 2On average, girls got their first period 1 year and 1 month after stopping treatment.
- 354% had menarche within 1 year, 44% by 2 years.
- 4Girls who were more developed before treatment started got their period sooner after stopping.
Score breakdown, methodology, COI, evidence analysis & raw study data
Publication
Journal
Annals of Pediatric Endocrinology & Metabolism
Year
2021
Authors
V. Wu, Victoria Zhao, Rula Issa, Meredith Wilkes, E. Wallach, R. Rapaport, C. Romero, M. Yau