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v1
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assertion
Analysis v1
Strong Support

In a 2019 study, tesamorelin improved mitochondrial function in obese people with low growth hormone, as measured by better phosphocreatine recovery after exercise, and this improvement was linked to increased IGF-1 levels.

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Evidence from Studies

Supporting (3)

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Community contributions welcome

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The effects of tesamorelin on phosphocreatine recovery in obese subjects with reduced GH.

Randomized Controlled Trial
Human
2014 Jan

The study found that a drug called tesamorelin boosted a growth-related hormone (IGF-I) in obese people with low growth hormone, and those who got the drug recovered faster after exercise—meaning their muscle energy systems worked better, likely because their cell power plants (mitochondria) improved.

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The effects of tesamorelin on phosphocreatine recovery in obese subjects with reduced GH.

Randomized Controlled Trial
Human
2014 Jan

This study directly looks at how tesamorelin affects muscle energy recovery in obese adults with low growth hormone, which is exactly what the claim is about.

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Supplemental Oxygen Improves In Vivo Mitochondrial Oxidative Phosphorylation Flux in Sedentary Obese Adults With Type 2 Diabetes

Randomized Controlled Trial
Human
2018 Jul

This study looks at how extra oxygen affects energy production in the bodies of obese adults with diabetes, which is somewhat similar to how tesamorelin might affect energy production in obese adults with low growth hormone.

Contradicting (0)

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No contradicting evidence found

Similar Assertions

When obese people with low growth hormone took a drug called tesamorelin for a year, their muscle energy recovery got better, which means their muscle cells may have become better at making energy.

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In obese people with low growth hormone taking tesamorelin, higher IGF-I levels are linked to better mitochondrial energy efficiency, measured by τPCr.

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83%

We know muscle energy recovery got better, but we don’t know if it’s because there are more mitochondria, bigger ones, or just ones that work better.

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83%

Because so few people finished the study and the muscle energy didn’t improve much more in the drug group than the placebo group, we can’t say for sure the drug caused the improvement.

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In obese people with low growth hormone taking tesamorelin, the link between higher IGF-I and better muscle energy recovery is even stronger than in the whole group of participants.

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