In blood vessel cells under high sugar conditions, uric acid makes them produce more inflammation markers, but insulin doesn't have this effect.
Scientific Claim
In human endothelial cells exposed to hyperglycemia (25 mM glucose), uric acid (0.5 mM) increases interleukin-6, interleukin-8, and interleukin-1β mRNA expression, but insulin (1 nM) does not (n=4 experiments, p < 0.05).
Original Statement
“Uric acid significantly increased the expression of IL-6, IL-8 and IL-1β mRNAs when compared with hyperglycaemia alone, which itself induced a significant pro-inflammatory response (Fig. 4A). On the contrary, insulin, either alone or in combination, did not modulate the expression of any of these mediators (Fig. 4A and B).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
In vitro experimental design allows causal language for the specific cell model. 'Increases' is appropriate for this controlled setting.
Evidence from Studies
Supporting (1)
Anti-inflammatory effect of SGLT-2 inhibitors via uric acid and insulin