When immune cells called monocytes are exposed to a bacterial toxin, adding uric acid and insulin together makes them produce more inflammation-related molecules than the toxin alone.
Scientific Claim
In human monocytes stimulated with lipopolysaccharide, uric acid (0.5 mM) and insulin (1 nM) together increase interleukin-6, interleukin-8, and interleukin-1β mRNA expression compared to lipopolysaccharide alone (n=4 experiments, p < 0.05).
Original Statement
“The combination of uric acid and insulin significantly increased mRNA expression of three inflammatory mediators, IL-6, IL-8 and IL-1β when compared with either LPS alone or LPS + uric acid, which itself potentiated the response induced by LPS (Fig. 3A).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
In vitro experimental design allows causal language for the specific cell model. 'Increase' is appropriate for this controlled setting.
Evidence from Studies
Supporting (1)
Anti-inflammatory effect of SGLT-2 inhibitors via uric acid and insulin