How SGLT-2 drugs fight inflammation by lowering uric acid and insulin
Anti-inflammatory effect of SGLT-2 inhibitors via uric acid and insulin
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
SGLT-2 drugs lower uric acid and insulin, which reduces inflammation. Tests show uric acid makes immune cells more inflamed, especially with insulin.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
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Evidence Score
A snapshot of a population at a single point in time. Can identify correlations and prevalence, but cannot determine the direction of cause and effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
SGLT-2 drugs lower uric acid and insulin, which reduces inflammation. Tests show uric acid makes immune cells more inflamed, especially with insulin.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 544 / 44
Evidence Score
A snapshot of a population at a single point in time. Can identify correlations and prevalence, but cannot determine the direction of cause and effect.
Publication
Authors
La Grotta R, de Candia P, Olivieri F, Matacchione G, Giuliani A, Rippo MR, Tagliabue E, Mancino M, Rispoli F, Ferroni S, Berra CC, Ceriello A, Prattichizzo F
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Claims (6)
People with type 2 diabetes who take SGLT-2 inhibitors tend to have lower levels of a key inflammation marker called interleukin-6 than those taking other diabetes medications.
Type 2 diabetes patients taking SGLT-2 inhibitors have lower levels of uric acid in their blood than those on other diabetes medications.
People with type 2 diabetes who take SGLT-2 inhibitors tend to have lower fasting insulin levels than those using other diabetes drugs.
When immune cells called monocytes are exposed to a bacterial toxin, adding uric acid and insulin together makes them produce more inflammation-related molecules than the toxin alone.
In blood vessel cells under high sugar conditions, uric acid makes them produce more inflammation markers, but insulin doesn't have this effect.