How SGLT-2 drugs fight inflammation by lowering uric acid and insulin
Anti-inflammatory effect of SGLT-2 inhibitors via uric acid and insulin
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
No direct anti-inflammatory effect from SGLT-2 inhibitors
Most assume the drugs themselves fight inflammation, but the study proves they only work by lowering uric acid/insulin—no drug-intrinsic effect.
Practical Takeaways
Ask your doctor to check uric acid levels if you have diabetes—lower levels may signal reduced inflammation risk.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
No direct anti-inflammatory effect from SGLT-2 inhibitors
Most assume the drugs themselves fight inflammation, but the study proves they only work by lowering uric acid/insulin—no drug-intrinsic effect.
Practical Takeaways
Ask your doctor to check uric acid levels if you have diabetes—lower levels may signal reduced inflammation risk.
Publication
Journal
Cellular and Molecular Life Sciences: CMLS
Year
2022
Authors
Rosalba La Grotta, P. de Candia, F. Olivieri, G. Matacchione, A. Giuliani, M. R. Rippo, E. Tagliabue, M. Mancino, Francesca Rispoli, Sabina Ferroni, C. Berra, A. Ceriello, F. Prattichizzo
Related Content
Claims (6)
People with type 2 diabetes who take SGLT-2 inhibitors tend to have lower levels of a key inflammation marker called interleukin-6 than those taking other diabetes medications.
Type 2 diabetes patients taking SGLT-2 inhibitors have lower levels of uric acid in their blood than those on other diabetes medications.
People with type 2 diabetes who take SGLT-2 inhibitors tend to have lower fasting insulin levels than those using other diabetes drugs.
When immune cells called monocytes are exposed to a bacterial toxin, adding uric acid and insulin together makes them produce more inflammation-related molecules than the toxin alone.
In blood vessel cells under high sugar conditions, uric acid makes them produce more inflammation markers, but insulin doesn't have this effect.