Kids with a rare genetic condition called Bardet-Biedl syndrome sometimes have underactive sex glands, and this might be linked to issues in the brain's hormone control center — meaning their body's hormone system could be involved in how the condition shows up.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

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Empty sellae, impaired testosterone secretion, and defective hypothalamic-pituitary growth and gonadal axes in children with Bardet-Biedl syndrome.

Case Report

The study shows that kids with Bardet-Biedl syndrome have problems with their sex hormones and also with the brain areas that control them, which supports the idea that multiple parts of the hormone system are involved.

Contradicting (0)

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Empty sellae, impaired testosterone secretion, and defective hypothalamic-pituitary growth and gonadal axes in children with Bardet-Biedl syndrome.

Score: 3

DOI: 10.1016/S0026-0495(96)90240-1

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