In healthy adults who reduced their calorie intake by 25% for two years, a molecular marker called DunedinPACE showed a 2–3% slower rate of biological aging, while other commonly used aging biomarkers did not change significantly.
Evidence from Studies
No evidence studies found yet.
What Would Prove This
Per GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this claim, ordered from strongest to weakest.
Whether sustained DunedinPACE reduction from caloric restriction consistently predicts reduced incidence of age-related disease and mortality across multiple long-term cohorts.
A systematic review and meta-analysis of all prospective cohort studies with at least 10 years of follow-up that measure DunedinPACE at baseline and track incidence of cardiovascular disease, type 2 diabetes, cancer, and all-cause mortality, adjusting for confounders such as BMI, smoking, and physical activity.
Whether caloric restriction-induced DunedinPACE reduction leads to reduced incidence of chronic disease or extended healthspan over a decade.
A multicenter, double-blind, placebo-controlled RCT of 1,000 healthy adults aged 40–60 randomized to 20% caloric restriction vs. control for 5 years, with DunedinPACE measured annually and primary endpoints being time to first diagnosis of cardiovascular disease, type 2 diabetes, or cancer.
Whether individuals with slower DunedinPACE trajectories over time have lower rates of morbidity and mortality independent of chronological age and lifestyle factors.
A prospective cohort study following 5,000 adults aged 30–50 for 20 years, measuring DunedinPACE every 5 years and tracking clinical outcomes including hospitalizations, functional decline, and death, with detailed covariate adjustment.
Whether individuals diagnosed with age-related diseases have significantly faster DunedinPACE trajectories compared to matched healthy controls prior to diagnosis.
A nested case-control study within a large biobank comparing DunedinPACE trajectories from blood samples collected 5–10 years before diagnosis in 500 individuals who developed cardiovascular disease or cancer versus 500 matched controls without disease.
Whether DunedinPACE levels at a single timepoint are associated with current health status or functional capacity in older adults.
A cross-sectional analysis of 2,000 adults aged 50–80 measuring DunedinPACE and assessing physical function, cognitive performance, and multimorbidity at one timepoint.