The Claim
In healthy men, daily oral desogestrel at 300 micrograms combined with a single 300 mg testosterone pellet administered for 8 weeks is associated with azoospermia in three out of ten participants and no significant metabolic or behavioral side effects.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In healthy men, taking 300 micrograms of desogestrel daily along with a 300 mg testosterone pellet for 8 weeks results in zero sperm count in three out of ten men, with no measurable changes in metabolism or behavior.
See the scientific wording
In healthy men, daily oral desogestrel at 300 micrograms combined with a single 300 mg testosterone pellet for 8 weeks is associated with azoospermia in three out of ten participants, indicating profound suppression of sperm production without significant metabolic or behavioral side effects.
A synthetic hormone in the pill and a testosterone implant together shut down the brain's signal to the testes, causing the testes to stop making sperm completely. The brain stops sending the signals that tell the testes to produce sperm and testosterone, and the implanted testosterone keeps male hormone levels stable so there are no side effects.
What the research says
1 studyIn a study, 10 healthy men took a daily pill and had a small implant; three of them ended up with no sperm at all, and none had bad side effects like mood changes or cholesterol problems. So yes, this combo can stop sperm production safely.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.