In kidney cells grown in a lab, insulin causes more URAT1 transporter to be present, which suggests insulin directly affects how kidneys handle uric acid. This finding is from the abstract summary - full study details were not available

In healthy rats, giving insulin makes the kidneys produce more URAT1 transporter and less ABCG2 transporter, which likely causes the kidneys to hold onto more uric acid instead of excreting it. This finding is from the abstract summary - full study details were not available