In healthy rats, giving insulin makes the kidneys produce more URAT1 transporter and less ABCG2 transporter, which likely causes the kidneys to hold onto more uric acid instead of excreting it. This finding is from the abstract summary - full study details were not available

When diabetic rats are given insulin, their kidneys excrete less uric acid, and the levels of key uric acid transporters (URAT1 and ABCG2) return to normal, which helps explain why insulin can affect uric acid levels. This finding is from the abstract summary - full study details were not available

In kidney cells grown in a lab, insulin causes more URAT1 transporter to be present, which suggests insulin directly affects how kidneys handle uric acid. This finding is from the abstract summary - full study details were not available