How insulin controls uric acid in kidneys
Insulin stimulates uric acid reabsorption via regulating urate transporter 1 and ATP-binding cassette subfamily G member 2.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Insulin directly regulates kidney urate transporters in a way not previously understood
Most people associate insulin only with blood sugar control, but this study shows it also directly controls uric acid handling in kidneys
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Surprising Findings
Insulin directly regulates kidney urate transporters in a way not previously understood
Most people associate insulin only with blood sugar control, but this study shows it also directly controls uric acid handling in kidneys
Publication
Journal
American journal of physiology. Renal physiology
Year
2017
Authors
Daigo Toyoki, S. Shibata, Emiko Kuribayashi-Okuma, N. Xu, Kenichi Ishizawa, M. Hosoyamada, S. Uchida
Related Content
Claims (6)
Elevated uric acid levels directly increase renal sodium reabsorption without insulin involvement.
When rats have diabetes caused by streptozotocin, their kidneys excrete more uric acid than normal rats, which means their bodies are getting rid of more uric acid through urine. This finding is from the abstract summary - full study details were not available
In diabetic rats, the kidneys show lower levels of the URAT1 transporter and higher levels of the ABCG2 transporter in the membrane parts of kidney cells, which helps explain why more uric acid is excreted. This finding is from the abstract summary - full study details were not available
When diabetic rats are given insulin, their kidneys excrete less uric acid, and the levels of key uric acid transporters (URAT1 and ABCG2) return to normal, which helps explain why insulin can affect uric acid levels. This finding is from the abstract summary - full study details were not available
In healthy rats, giving insulin makes the kidneys produce more URAT1 transporter and less ABCG2 transporter, which likely causes the kidneys to hold onto more uric acid instead of excreting it. This finding is from the abstract summary - full study details were not available