Uric acid makes your kidneys hold onto more salt, even without insulin being involved.
Scientific Claim
Elevated uric acid levels directly increase renal sodium reabsorption without insulin involvement.
Original Statement
“It also increases renal sodium reabsorption directly independent of insulin.”
Context Details
Domain
cardiology
Population
human
Subject
elevated uric acid
Action
increases
Target
renal sodium reabsorption
Intervention Details
Evidence from Studies
Supporting (2)
This study found that insulin helps the kidneys reabsorb uric acid, which is related to how the kidneys handle sodium.
This study found that high uric acid levels can increase blood pressure in rats through a specific mechanism that could involve how the kidneys handle sodium.
Contradicting (2)
Anti-inflammatory effect of SGLT-2 inhibitors via uric acid and insulin
This study found that a certain type of diabetes medication can lower uric acid and insulin levels, which might affect how the kidneys handle sodium.
This study found that insulin affects how the kidneys handle sodium and uric acid in people with high blood pressure.