When diabetic rats are given insulin, their kidneys excrete less uric acid, and the levels of key uric acid transporters (URAT1 and ABCG2) return to normal, which helps explain why insulin can affect uric acid levels. This finding is from the abstract summary - full study details were not available

When rats have diabetes caused by streptozotocin, their kidneys excrete more uric acid than normal rats, which means their bodies are getting rid of more uric acid through urine. This finding is from the abstract summary - full study details were not available

In diabetic rats, the kidneys show lower levels of the URAT1 transporter and higher levels of the ABCG2 transporter in the membrane parts of kidney cells, which helps explain why more uric acid is excreted. This finding is from the abstract summary - full study details were not available

In healthy rats, giving insulin makes the kidneys produce more URAT1 transporter and less ABCG2 transporter, which likely causes the kidneys to hold onto more uric acid instead of excreting it. This finding is from the abstract summary - full study details were not available