For kids who've had a kidney transplant and are taking a drug called sirolimus (but not certain other drugs), checking the lowest level of the drug in their blood helps doctors figure out how much of the drug their body is getting overall.

36

Pro

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Against

Evidence from Studies

Supporting (1)

36

Community contributions welcome

36

Short sirolimus half‐life in pediatric renal transplant recipients on a calcineurin inhibitor‐free protocol

Cross-Sectional Study

Human

2004 Apr

The study looked at kids who had kidney transplants and were taking sirolimus without certain other drugs, and found that checking their blood levels at the lowest point (trough) reliably shows how much of the drug is in their body overall.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Short sirolimus half‐life in pediatric renal transplant recipients on a calcineurin inhibitor‐free protocol

Score: 36

DOI: 10.1046/j.1399-3046.2003.00148.x

Similar Assertions

In kids who got a kidney transplant and are on a certain anti-rejection drug combo, taking more or less of one drug (mycophenolic acid) doesn’t change how the body handles another drug (sirolimus).

36

0

82%

Kids who got a kidney transplant and are taking a drug called sirolimus clear it from their bodies faster than adults do, especially in the first few months after surgery.

36

0

74%