How long does medicine stay in kids' bodies after a kidney transplant?
Short sirolimus half‐life in pediatric renal transplant recipients on a calcineurin inhibitor‐free protocol
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Doctors gave a drug called sirolimus to kids after kidney transplants and checked how long it stayed in their bodies. They found it leaves faster in kids than in adults, so they might need to take it more often.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
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Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
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Evidence Score
A snapshot of a population at a single point in time. Can identify correlations and prevalence, but cannot determine the direction of cause and effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Doctors gave a drug called sirolimus to kids after kidney transplants and checked how long it stayed in their bodies. They found it leaves faster in kids than in adults, so they might need to take it more often.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 536 / 44
Evidence Score
A snapshot of a population at a single point in time. Can identify correlations and prevalence, but cannot determine the direction of cause and effect.
Publication
Authors
Schachter AD, Meyers KE, Spaneas LD, Palmer JA, Salmanullah M, Baluarte J, Brayman KL, Harmon WE
Related Content
Claims (4)
Sirolimus stays in your body for a long time—about 2.5 days—so even if you take it just once a week, it might still be active when you work out again.
In kids who got a kidney transplant and are on a certain anti-rejection drug combo, taking more or less of one drug (mycophenolic acid) doesn’t change how the body handles another drug (sirolimus).
Kids who got a kidney transplant and are taking a drug called sirolimus clear it from their bodies faster than adults do, especially in the first few months after surgery.
For kids who've had a kidney transplant and are taking a drug called sirolimus (but not certain other drugs), checking the lowest level of the drug in their blood helps doctors figure out how much of the drug their body is getting overall.