The Claim
The terminal half-life of sirolimus (rapamycin) is approximately 62 hours, which results in prolonged systemic exposure that can persist into subsequent exercise sessions even when administered once weekly.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Sirolimus stays in your body for a long time—about 2.5 days—so even if you take it just once a week, it might still be active when you work out again.
See the scientific wording
The terminal half-life of sirolimus (rapamycin) is approximately 62 hours, leading to persistent systemic exposure that may overlap with subsequent exercise sessions even with once-weekly dosing.
What the research says
3 studiesThe study gives rapamycin once a week and sees effects throughout the week, which makes sense if the drug stays in the body for a long time—like the claim says.
Study: Pharmacokinetic analysis of intermittent rapamycin administration in early-stage Alzheimer's Disease
The study looked at how long rapamycin stays in the body when taken once a week and found it takes about 69 hours to drop by half, which is close to the 62 hours mentioned in the claim. This means the drug sticks around long enough to overlap with the next dose, supporting the idea of lasting effects.
Related videos
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 3 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.