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Strong Support

In lean men, insulin reduces the activity of an enzyme in fat tissue that regulates cortisol, but this reduction does not occur in obese men, suggesting a difference in how insulin affects cortisol processing in fat tissue between these groups.

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Evidence from Studies

Supporting (1)

55

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55

Increased in vivo regeneration of cortisol in adipose tissue in human obesity and effects of the 11beta-hydroxysteroid dehydrogenase type 1 inhibitor carbenoxolone.

Randomized Controlled Trial
Human
2005 Mar

In lean people, insulin tells fat tissue to make less of the stress hormone cortisol, but in obese people, this signal doesn’t work — like a broken radio. The study proves insulin can’t control cortisol production in fat tissue of obese individuals.

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Source Study

Increased in vivo regeneration of cortisol in adipose tissue in human obesity and effects of the 11beta-hydroxysteroid dehydrogenase type 1 inhibitor carbenoxolone.

Score: 55
DOI: 10.2337/DIABETES.54.3.872

Similar Assertions

In obese men, the enzyme 11β-hydroxysteroid dehydrogenase type 1 converts inactive cortisol to its active form at higher rates in abdominal fat tissue than in lean men, even though overall cortisol production in the body is similar between the two groups.

55
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79%

Insulin by itself doesn’t change estrogen production in fat, but when it’s with cortisol, it makes the difference between men and women disappear.

38
0
72%

In men with obesity, the drug carbenoxolone does not improve insulin sensitivity as effectively as it does in men with normal weight, suggesting that obesity alters how the body responds to this type of treatment.

55
0
72%

In Chinese adults, people with higher levels of a specific enzyme (11beta-HSD1) in their belly fat tend to also have higher body weight, as measured by BMI.

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71%