Analysis Version
v1
History
Back to Study: Increased in vivo regeneration of cortisol in adip...
mechanistic
Analysis v1
Strong Support

In men with obesity, the drug carbenoxolone does not improve insulin sensitivity as effectively as it does in men with normal weight, suggesting that obesity alters how the body responds to this type of treatment.

55
Pro
0
Against

Evidence from Studies

Supporting (1)

55

Community contributions welcome

55

Increased in vivo regeneration of cortisol in adipose tissue in human obesity and effects of the 11beta-hydroxysteroid dehydrogenase type 1 inhibitor carbenoxolone.

Randomized Controlled Trial
Human
2005 Mar

The study found that a drug called carbenoxolone helps lean men become more sensitive to insulin, but it doesn’t work as well in obese men — meaning their bodies don’t respond the same way to the treatment.

Contradicting (0)

0

Community contributions welcome

No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Increased in vivo regeneration of cortisol in adipose tissue in human obesity and effects of the 11beta-hydroxysteroid dehydrogenase type 1 inhibitor carbenoxolone.

Score: 55
DOI: 10.2337/DIABETES.54.3.872

Similar Assertions

In obese men, a drug called carbenoxolone does not block a specific enzyme in fat tissue that regulates stress hormones, suggesting that existing drugs of this type are not strong enough or cannot reach the fat tissue effectively to change metabolism.

55
0
90%

Carbenoxolone, a drug that blocks an enzyme involved in cortisol production, lowers cortisol regeneration throughout the body in obese men, but it does not significantly reduce cortisol regeneration in abdominal fat tissue or improve how the body responds to insulin.

55
0
77%

In lean men, insulin reduces the activity of an enzyme in fat tissue that regulates cortisol, but this reduction does not occur in obese men, suggesting a difference in how insulin affects cortisol processing in fat tissue between these groups.

55
0
72%