The Claim

Angiotensin II and vasopressin increase the phosphorylation of 10 to 12 cytosolic proteins in isolated hepatocytes through a calcium-dependent, cyclic AMP-independent pathway, and this phosphorylation is associated with increased phosphorylase activity (250–260%), decreased glycogen synthase activity (50%), and decreased pyruvate kinase activity (30–70%).

Source: The role of calcium ion as a mediator of the effects of angiotensin II, catecholamines, and vasopressin on the phosphorylation and activity of enzymes in isolated hepatocytes.

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
34score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
1 study reviewed
In plain English

Angiotensin II and vasopressin trigger the addition of phosphate groups to 10 to 12 proteins in liver cells, which correlates with a 250–260% rise in phosphorylase activity, a 50% drop in glycogen synthase activity, and a 30–70% drop in pyruvate kinase activity.

See the scientific wording

Angiotensin II and vasopressin increase the phosphorylation of 10 to 12 cytosolic proteins in isolated hepatocytes through a calcium-dependent, cyclic AMP-independent pathway, and this phosphorylation is associated with increased phosphorylase activity (250–260%), decreased glycogen synthase activity (50%), and decreased pyruvate kinase activity (30–70%).

Why this might work

When angiotensin II or vasopressin bind to liver cells, they trigger a surge of calcium inside the cells, which turns on specific enzymes that add phosphate groups to other enzymes. This phosphate addition activates the enzyme that breaks down glycogen into glucose, while turning off the enzymes that build glycogen or convert sugar into energy, forcing the liver to release glucose into the blood.

Verified mechanismbased on 1 study

What the research says

1 study

  1. Study: The role of calcium ion as a mediator of the effects of angiotensin II, catecholamines, and vasopressin on the phosphorylation and activity of enzymes in isolated hepatocytes.

    The study shows that two hormones, angiotensin II and vasopressin, make liver cells release sugar by turning on one enzyme and turning off two others—and they do this using calcium, not the usual sugar-signaling system. This matches exactly what the claim said.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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