In mice, a type of gut bacteria called Sphingomonas paucimobilis moves to belly fat during inflammation and blocks the body’s ability to burn calories for heat by interfering with a key fat-burning chemical and its signaling pathway.

Pro

Against

Evidence from Studies

Supporting (1)

Community contributions welcome

Adipose Tissue‐Resident <i>Sphingomonas Paucimobilis</i> Suppresses Adaptive Thermogenesis by Reducing 15‐HETE Production and Inhibiting AMPK Pathway

Cohort Study

Human

2024 Dec

In mice with chronic inflammation, a specific gut bacterium called Sphingomonas paucimobilis ends up in fat tissue and blocks a key process that helps burn calories, by reducing a helpful molecule (15-HETE) that normally turns on energy-burning machinery in fat cells.

Contradicting (0)

Community contributions welcome

No contradicting evidence found

Source Study

Adipose Tissue‐Resident <i>Sphingomonas Paucimobilis</i> Suppresses Adaptive Thermogenesis by Reducing 15‐HETE Production and Inhibiting AMPK Pathway

Score: 53

DOI: 10.1002/advs.202310236

Similar Assertions

When scientists grew fat cells with this specific bacteria (Sphingomonas), the cells stopped making a key fat-burning chemical and heat-producing proteins—but when they used a different common bacteria (E. coli), nothing changed.

76%

When scientists gave a specific fat chemical (15-HETE) to mice whose heat production was blocked, it brought back their ability to burn fat and generate heat, even if the bacteria or enzyme blocking it were still present.

75%