When scientists grew fat cells with this specific bacteria (Sphingomonas), the cells stopped making a key fat-burning chemical and heat-producing proteins—but when they used a different common bacteria (E. coli), nothing changed.

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Adipose Tissue‐Resident <i>Sphingomonas Paucimobilis</i> Suppresses Adaptive Thermogenesis by Reducing 15‐HETE Production and Inhibiting AMPK Pathway

Cohort Study

Human

2024 Dec

This study found that a specific gut bacterium called Sphingomonas paucimobilis slows down fat-burning in mice by lowering a key molecule (15-HETE), which in turn turns down heat-producing proteins in fat cells—while other bacteria like E. coli weren’t tested but didn’t show the same effect.

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Source Study

Adipose Tissue‐Resident <i>Sphingomonas Paucimobilis</i> Suppresses Adaptive Thermogenesis by Reducing 15‐HETE Production and Inhibiting AMPK Pathway

Score: 53

DOI: 10.1002/advs.202310236

Similar Assertions

When scientists gave a specific fat chemical (15-HETE) to mice whose heat production was blocked, it brought back their ability to burn fat and generate heat, even if the bacteria or enzyme blocking it were still present.

83%

In mice, a type of gut bacteria called Sphingomonas paucimobilis moves to belly fat during inflammation and blocks the body’s ability to burn calories for heat by interfering with a key fat-burning chemical and its signaling pathway.

76%