When mice are genetically changed so they don’t break down a certain nutrient (tryptophan) as much, it might help them live longer and healthier — and this could mean the same process matters for aging in other animals, including people.

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Evidence from Studies

Supporting (1)

6

Community contributions welcome

6

MULTIMODEL APPROACHES IDENTIFY CONSERVED ROLE OF TRP CATABOLIC PATHWAY IN THE REGULATION OF LIFE- AND HEALTHSPAN

Cohort Study

Animal

The study looked at mice genetically changed to block a specific pathway that breaks down a nutrient called tryptophan, and found this change may help them live healthier longer, which supports the idea that this pathway affects aging.

Contradicting (0)

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No contradicting evidence found

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According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

MULTIMODEL APPROACHES IDENTIFY CONSERVED ROLE OF TRP CATABOLIC PATHWAY IN THE REGULATION OF LIFE- AND HEALTHSPAN

Score: 6

DOI: 10.1093/geroni/igae098.2630

Similar Assertions

Blocking a specific enzyme in fruit flies and tiny worms helps them live longer, suggesting that changing how their bodies process a certain nutrient can slow aging in these animals.

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Your body uses a special chemical pathway to turn tryptophan from food into energy molecules, and this process might be linked to how we age and manage energy in our cells.

6

0

70%