The Claim
Creatine supplementation in a syngeneic mouse melanoma model (B16-OVA) increases the abundance and activation of type 1 dendritic cells (cDC1s) in tumors and reduces tumor growth.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In mice with melanoma, creatine supplementation increases the number and activity of type 1 dendritic cells in tumors and decreases tumor size.
See the scientific wording
Creatine supplementation in a syngeneic mouse melanoma model (B16-OVA) increases the abundance and activation of type 1 dendritic cells (cDC1s) in tumors and reduces tumor growth, suggesting a potential role for creatine in enhancing antitumor immunity through dendritic cell modulation.
Immune cells in the tumor take up creatine from the blood, convert it into a stored energy form, and use that energy to stay active and send strong signals. This keeps their energy levels high, allowing them to turn on key inflammatory pathways that make them better at alerting killer immune cells to attack the tumor. As a result, more killer cells enter the tumor and stop it from growing.
What the research says
1 studyStudy: Creatine uptake promotes dendritic cell activation and enhances antitumor immunity
In mice with skin cancer, giving creatine helped immune cells called cDC1s work better and grow in number inside tumors, which made the tumors grow slower. The same thing happened with human immune cells in the lab.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.