A plant extract from Bombax ceiba has been shown in laboratory cell studies to improve the movement of glucose transporters to the cell membrane in muscle cells exposed to high sugar levels, which...
Mechanism
Synthesis from 1 study
The plant extract contains natural chemicals that help muscle cells respond better to insulin. This lets more sugar get pulled out of the blood and into the cells, which lowers blood sugar levels. We know this happens because the extract fixes the sugar uptake problem in cells damaged by too much...
Most probable mechanism
Natural compounds in the plant extract enter the bloodstream and help muscle cells respond better to insulin. This lets more sugar-carrying transporters move to the cell surface, so sugar can enter the cells and blood sugar levels drop.
Bioactive phytometabolites (e.g., flavonoids and phenolic acids) are absorbed into circulation after ingestion
These compounds activate insulin signaling pathways in skeletal muscle cells, increasing phosphorylation of IRS-1, PI3K, and Akt
Activated Akt triggers the movement of GLUT4 glucose transporters from intracellular vesicles to the cell membrane
GLUT4 transporters on the cell membrane increase glucose uptake into muscle cells, reversing insulin resistance caused by high glucose
Evidence from Studies
Supporting (1)
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