In mice with obesity, the drug semaglutide is linked to lower activity of specific genes produced by neutrophils that are normally increased during obesity, which may help reduce inflammation in the...
Mechanism
Synthesis from 1 study
In obese mice, semaglutide appears to quiet down overactive immune cells called neutrophils, which normally flood the heart with harmful chemicals. When these chemicals drop, less damage occurs in heart tissue, helping protect it from inflammation. The evidence strongly links this effect to...
Most probable mechanism
Semaglutide helps calm down overactive immune cells called neutrophils in obese mice. These cells normally release chemicals that attract more immune cells and cause damage in the heart. When semaglutide is given, these harmful chemicals drop, so fewer immune cells enter the heart, less damage occurs, and the heart stays healthier.
Semaglutide activates GLP-1 receptors on immune cells or alters systemic metabolic signals, leading to reduced activation of neutrophils
Reduced expression of Cxcl2 in neutrophils decreases chemotactic signaling that recruits additional neutrophils and monocytes to cardiac tissue
Lower levels of S100a8 and S100a9 in neutrophils reduce formation of the calprotectin complex, diminishing activation of TLR4/NF-κB pathways and subsequent reactive oxygen species production
Decreased neutrophil-derived inflammatory signals reduce activation of cardiac macrophages and endothelial cells, lowering local production of TNF-α, IL-6, and reactive oxygen species
Reduced inflammation and oxidative stress in cardiac tissue attenuates myocardial damage
Evidence from Studies
Supporting (1)
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