How a diabetes drug might protect the heart in obese mice
Semaglutide ameliorates obesity-induced cardiac inflammation and oxidative stress mediated via reduction of neutrophil Cxcl2, S100a8, and S100a9 expression
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
A drug called semaglutide, used for diabetes and weight loss, was given to obese mice to see if it helped their hearts. Scientists found it lowered harmful chemicals and turned down genes in immune cells called neutrophils that were causing heart inflammation.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 512 / 72
Evidence Score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
A drug called semaglutide, used for diabetes and weight loss, was given to obese mice to see if it helped their hearts. Scientists found it lowered harmful chemicals and turned down genes in immune cells called neutrophils that were causing heart inflammation.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 512 / 72
Evidence Score
Groups of people are followed over time to see who develops an outcome. Strong for identifying risk factors and associations, but cannot prove causation as firmly as RCTs.
Publication
Authors
Pan X, Yang L, Wang S, Liu Y, Yue L, Chen S
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Claims (5)
In mice with obesity, the drug semaglutide is linked to lower levels of certain biological markers that indicate inflammation and oxidative stress in the blood and heart tissue.
In mice with obesity, the drug semaglutide is linked to lower activity of certain genes in heart tissue that are related to neutrophils, a type of immune cell.
In mice with obesity, a medication called semaglutide is linked to weight loss, and this weight loss may be related to lower levels of inflammation and oxidative stress in the heart.
In mice with obesity, a type of immune cell called neutrophils in the heart show increased activity of specific genes linked to inflammation, which may be related to heart stress caused by obesity.
In mice with obesity, the drug semaglutide is linked to lower activity of specific genes produced by neutrophils that are normally increased during obesity, which may help reduce inflammation in the heart.