The Claim
In adults with type 2 diabetes, higher postprandial glucagon-to-C-peptide index ratios are associated with reduced time in glucose target range, increased time above glucose target range, and higher average glucose levels.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In adults with type 2 diabetes, a higher ratio of glucagon to C-peptide after meals is linked to less time spent in the normal blood glucose range, more time spent with high blood glucose, and higher average blood glucose levels.
See the scientific wording
In adults with type 2 diabetes, higher postprandial glucagon-to-C-peptide index ratios are associated with reduced time in glucose target range (TIR), increased time above range (TAR), and higher average glucose levels, suggesting that dysregulated glucagon secretion relative to insulin secretion correlates with poorer glycemic stability.
After eating, the pancreas releases too much glucagon and not enough insulin, causing the liver to make and release more sugar than needed. This floods the bloodstream with glucose, keeping blood sugar high for longer and causing wild swings in glucose levels.
What the research says
1 studyStudy: 77-OR: Time in Range Is Associated with Glucagon/C-Peptide Index Ratio in Type 2 Diabetes Patients
In people with type 2 diabetes, when the body releases too much glucagon compared to insulin after eating, their blood sugar stays higher and swings more wildly. This study found that this imbalance directly links to worse blood sugar control.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.