The Study
77-OR: Time in Range Is Associated with Glucagon/C-Peptide Index Ratio in Type 2 Diabetes Patients
This study looked at a group of people with type 2 diabetes and found that those with higher glucagon levels tended to have more unstable blood sugar. But it didn’t change anything—it just watched and recorded. So we can’t say glucagon makes blood sugar go up, only that they’re linked.
Analysis score
Maximum 44 for a cross-sectional study.
Where the score came from
This study looked at how two things — too much glucagon (a hormone that raises blood sugar) and too much belly fat — might make blood sugar levels jump around more in people with type 2 diabetes.
Where does this study sit?
Reviews of RCTs (Meta-analyses)
Max 100Randomized Trials
Max 90Reviews of Cohort Studies
Max 85Cohort Studies
Max 72Reviews of Case-Control Studies
Max 63Case-Control Studies
Max 58Cross-Sectional & Case Series
Max 50Expert Opinion
Max 544 / 100
Quality score
Snapshots of a population at a single point in time, or descriptions of small groups. Can identify correlations and prevalence, but cannot determine cause and effect.
Key takeaways
Summary
Based on the study abstract and findings.
- 1Yes — these differences are clinically meaningful: lower time in range and higher glucose swings increase risk of complications like nerve damage and heart disease.
- 2People with higher glucagon-to-insulin ratios had 16% less time in healthy blood sugar range, 15% higher average blood sugar, and 21% more glucose swings.
- 3Those with more belly fat had 45% stronger link to glucose swings.
Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data
Publication
Journal
Diabetes
Year
2024
Authors
Miki Kamigishi, Daisuke Chujo, A. Takikawa, Shinya Inagawa, Asako Enkaku, Seiichiro Ohgaku, Atsushi Sato, Shinnosuke Matsukoshi, Hisae Honoki, S. Fujisaka, Kazuyuki Tobe
Related Content
Claims (5)
In adults with type 2 diabetes, a higher ratio of glucagon to C-peptide after meals is linked to more variable blood glucose levels, measured as greater standard deviation in glucose readings.
In adults with type 2 diabetes, a higher ratio of glucagon to C-peptide after meals is linked to less time spent in the normal blood glucose range, more time spent with high blood glucose, and higher average blood glucose levels.
In adults with type 2 diabetes, higher amounts of visceral fat are linked to more fluctuation in blood glucose levels and less time spent within the normal glucose range.
In adults with type 2 diabetes, higher ratios of glucagon to C-peptide after meals are linked to higher average blood glucose levels, indicating that excess glucagon relative to insulin production contributes to persistently high blood sugar.
In adults with type 2 diabetes, greater amounts of fat around the abdomen are linked to less time spent with blood glucose levels in the healthy range and more time spent with blood glucose levels too high.
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.