The Claim
In adults with type 2 diabetes, higher postprandial glucagon-to-C-peptide index ratios are associated with greater glucose fluctuations, as measured by higher standard deviation of glucose.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In adults with type 2 diabetes, a higher ratio of glucagon to C-peptide after meals is linked to more variable blood glucose levels, measured as greater standard deviation in glucose readings.
See the scientific wording
In adults with type 2 diabetes, higher postprandial glucagon-to-C-peptide index ratios are associated with greater glucose fluctuations, as measured by higher standard deviation of glucose, suggesting hormonal imbalance contributes to glycemic instability.
After eating, the pancreas releases too much glucagon and not enough insulin, causing the liver to make and release more sugar into the blood than needed. Without enough insulin to stop this process or help muscles absorb the sugar, blood glucose rises sharply and stays high, then drops unpredictably as the body struggles to correct the imbalance.
What the research says
1 studyStudy: 77-OR: Time in Range Is Associated with Glucagon/C-Peptide Index Ratio in Type 2 Diabetes Patients
In people with type 2 diabetes, when the hormone glucagon is high compared to insulin after eating, their blood sugar tends to swing up and down more wildly — and this study found that exact link in patients using glucose monitors.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.