In rat blood vessels, a ketone body relaxed heart, brain, leg, and gut arteries more easily than kidney arteries, with heart arteries responding at lower doses.
Scientific Claim
In isolated rat arteries, sodium 3-hydroxybutyrate relaxed coronary, cerebral, femoral, and mesenteric arteries but had minimal effect on renal interlobar arteries, with vasorelaxation beginning at 1–3 mM in coronary arteries and 6–10 mM in other arteries.
Original Statement
“3-OHB relaxed caudal femoral, middle cerebral, and mesenteric arteries in a concentration-dependent manner, beginning at 6–10 mM (Fig. 4C–H). In contrast, the tone of renal interlobar arteries was only minimally reduced in response to 3-OHB even at a concentration of 10 mM (Fig. 4I). The particularly pronounced coronary vasorelaxation begins at 1–3 mM, shows an EC50 value of 12.4 mM (Fig. 3B)...”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
The direct comparison of multiple vascular beds in isolated tissues supports definitive descriptive statements for the model.
Evidence from Studies
Supporting (1)
Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility