In rat heart arteries, a ketone body relaxed the blood vessels starting at low concentrations, with the strongest effect at higher doses.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

definitive

Can make definitive causal claims

Assessment Explanation

The controlled ex vivo experiments with precise concentration measurements support definitive quantitative statements for the model.

Evidence from Studies

Supporting (1)

14

Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility

Randomized Controlled Trial

Animal

2023 Sep 9

Contradicting (0)

0

No contradicting evidence found

Source Study

Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility

Score: 14

DOI: 10.1007/s00395-023-01008-y

Similar Assertions

Both versions of the ketone body (D and L) relaxed rat heart arteries equally, showing the effect doesn't depend on which version is used.

14

0

79%

In rat heart arteries, the ketone body relaxes blood vessels without needing the inner lining or certain inflammatory chemicals.

14

0

78%

In rat blood vessels, a ketone body relaxed heart, brain, leg, and gut arteries more easily than kidney arteries, with heart arteries responding at lower doses.

14

0

72%