Analysis Version
v1
History
Back to Study: Ketone body 3-hydroxybutyrate elevates cardiac out...
mechanistic
Analysis v1
14
Pro
0
Against

In rat heart arteries, the ketone body relaxes blood vessels without needing the inner lining or certain inflammatory chemicals.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

definitive

Can make definitive causal claims

Assessment Explanation

The targeted mechanistic experiments in isolated tissues support definitive statements about the underlying process.

Evidence from Studies

Supporting (1)

14
14

Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility

Randomized Controlled Trial
Animal
2023 Sep 9

Contradicting (0)

0
No contradicting evidence found

Source Study

Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility

Score: 14
DOI: 10.1007/s00395-023-01008-y

Similar Assertions

Both versions of the ketone body (D and L) relaxed rat heart arteries equally, showing the effect doesn't depend on which version is used.

14
0
81%

In rat heart arteries, a ketone body relaxed the blood vessels starting at low concentrations, with the strongest effect at higher doses.

14
0
78%