Analysis Version
v1
History
Back to Study: Ketone body 3-hydroxybutyrate elevates cardiac out...
descriptive
Analysis v1
14
Pro
0
Against

Both versions of the ketone body (D and L) relaxed rat heart arteries equally, showing the effect doesn't depend on which version is used.

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

definitive

Can make definitive causal claims

Assessment Explanation

The controlled enantiomer testing in isolated tissues supports definitive descriptive statements for the model.

Evidence from Studies

Supporting (1)

14
14

Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility

Randomized Controlled Trial
Animal
2023 Sep 9

Contradicting (0)

0
No contradicting evidence found

Source Study

Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility

Score: 14
DOI: 10.1007/s00395-023-01008-y

Similar Assertions

In rat heart arteries, the ketone body relaxes blood vessels without needing the inner lining or certain inflammatory chemicals.

14
0
81%

In rat heart arteries, a ketone body relaxed the blood vessels starting at low concentrations, with the strongest effect at higher doses.

14
0
79%

In rat blood vessels, a ketone body relaxed heart, brain, leg, and gut arteries more easily than kidney arteries, with heart arteries responding at lower doses.

14
0
71%