Both versions of the ketone body (D and L) relaxed rat heart arteries equally, showing the effect doesn't depend on which version is used.

Scientific Claim

The D- and L-enantiomers of sodium 3-hydroxybutyrate induced similar vasorelaxation in isolated rat coronary arteries, indicating no stereospecificity in this effect.

Original Statement

“The coronary septal arteries relaxed at similar rate and with similar magnitude when exposed separately to the two enantiomers D-3-OHB (Fig. 3C) and L-3-OHB (Fig. 3D).”

From study:Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility

Evidence Quality Assessment

Claim Status

appropriately stated

Study Design Support

Design supports claim

Appropriate Language Strength

definitive

Can make definitive causal claims

Assessment Explanation

The controlled enantiomer testing in isolated tissues supports definitive descriptive statements for the model.

Evidence from Studies

Supporting (1)

Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility

Randomized Controlled Trial

Animal

2023 Sep 9

Contradicting (0)

No contradicting evidence found

Source Study

Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility

Score: 14

DOI: 10.1007/s00395-023-01008-y

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