The Claim
The cytotoxic effect of cyclocreatine in C6 rat glioma cells is likely due to phosphocyclocreatine accumulation and subsequent cellular swelling, while its growth-inhibitory effects in OC238 human ovarian carcinoma cells occur through a different, unidentified mechanism that does not involve phosphocyclocreatine accumulation or cellular swelling.
What the research says
Roughly balanced
Support and challenge are close. The picture may shift as more studies come in.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
Cyclocreatine kills brain tumor cells in rats by making them swell up, but it stops ovarian cancer cells in humans in a totally different way we don’t yet understand.
See the scientific wording
The cytotoxic effect of cyclocreatine in C6 rat glioma cells may result from phosphocyclocreatine accumulation and associated cellular swelling, whereas a different, unidentified mechanism must account for its growth-inhibitory effects in OC238 human ovarian carcinoma cells where neither phosphocyclocreatine accumulation nor swelling occurs.
What the research says
1 studyThe study shows that cyclocreatine harms brain cancer cells by building up a toxic substance and making them swell, but it harms ovarian cancer cells in a different, unknown way.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.