Cyclocreatine kills brain tumor cells in rats by making them swell up, but it stops ovarian cancer cells in humans in a totally different way we don’t yet understand.

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Evidence from Studies

Supporting (1)

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Community contributions welcome

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Cyclocreatine transport and cytotoxicity in rat glioma and human ovarian carcinoma cells: 31P-NMR spectroscopy.

Cross-Sectional Study

Animal

1996 Jan

The study shows that cyclocreatine harms brain cancer cells by building up a toxic substance and making them swell, but it harms ovarian cancer cells in a different, unknown way.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Cyclocreatine transport and cytotoxicity in rat glioma and human ovarian carcinoma cells: 31P-NMR spectroscopy.

Score: 6

DOI: 10.1152/AJPCELL.1996.270.1.C160

Similar Assertions

Cyclocreatine slows down the growth of certain cancer cells in a lab dish, but it doesn’t harm their outer layer or energy supply — so it probably works in a different way.

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When scientists gave a substance called cyclocreatine to two types of cancer cells, one kind (from rat brain tumors) stored a modified version of it, but the other kind (from human ovarian tumors) didn't — meaning these cells handle the substance differently.

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