How a creatine-like drug affects cancer cells
Cyclocreatine transport and cytotoxicity in rat glioma and human ovarian carcinoma cells: 31P-NMR spectroscopy.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists tested a drug called cyclocreatine on two types of cancer cells to see how it stops them from growing.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
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Evidence Score
A snapshot of a population at a single point in time. Can identify correlations and prevalence, but cannot determine the direction of cause and effect.
Not medical advice. For informational purposes only. Always consult a healthcare professional. Terms
Scientists tested a drug called cyclocreatine on two types of cancer cells to see how it stops them from growing.
No biological mechanisms were identified in this study. This may be an epidemiological, observational, or survey-based study that reports associations rather than proposing causal biological pathways.
Systematic Reviews & Meta-Analyses
Max 100Randomized Controlled Trials
Max 90Cohort Studies
Max 72Case-Control Studies
Max 58Cross-Sectional Studies
Max 44Case Reports & Case Series
Max 30Expert Opinion & Narrative Reviews
Max 56 / 44
Evidence Score
A snapshot of a population at a single point in time. Can identify correlations and prevalence, but cannot determine the direction of cause and effect.
Publication
Authors
Schiffenbauer YS, Meir G, Cohn M, Neeman M
Related Content
Claims (4)
Cyclocreatine slows down the growth of certain cancer cells in a lab dish, but it doesn’t harm their outer layer or energy supply — so it probably works in a different way.
When scientists gave a substance called cyclocreatine to two types of cancer cells, one kind (from rat brain tumors) stored a modified version of it, but the other kind (from human ovarian tumors) didn't — meaning these cells handle the substance differently.
In rat brain tumor cells, a substance called cyclocreatine gets pulled in using energy and sodium, but when sugar levels drop, this process slows down a lot—showing it needs energy from sugar to work well.
Cyclocreatine kills brain tumor cells in rats by making them swell up, but it stops ovarian cancer cells in humans in a totally different way we don’t yet understand.