When insulin is present, certain parts of a pump in rat muscle cells move to the surface of the cell—these parts work together like a team that responds to insulin.

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Pro

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Against

Evidence from Studies

Supporting (1)

6

Community contributions welcome

6

Insulin induces translocation of the alpha 2 and beta 1 subunits of the Na+/K(+)-ATPase from intracellular compartments to the plasma membrane in mammalian skeletal muscle.

Cohort Study

Animal

Insulin makes certain parts of a pump (alpha 2 and beta 1) move from inside the muscle cell to the surface, and the study shows these two parts move together — meaning they probably work as a team that insulin controls.

Contradicting (0)

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Insulin induces translocation of the alpha 2 and beta 1 subunits of the Na+/K(+)-ATPase from intracellular compartments to the plasma membrane in mammalian skeletal muscle.

Score: 6

DOI: 10.1016/s0021-9258(18)42725-1

Similar Assertions

When rats are given insulin, a specific part of a pump in their muscle cells moves from inside the cell to the outer membrane, but another similar part stays where it is.

6

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When rats are given insulin, a specific part of a pump in their muscle cells (called the beta 1 subunit) becomes more active and shows up more in the cell’s outer layer, but another similar part (beta 2) stays the same.

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When you eat, your body releases insulin, which helps muscle cells pull more potassium from your blood by putting more pumps on their surface—this keeps your muscles working smoothly after meals.

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When insulin is added to rat muscle cells, it turns down a specific molecular switch (phosphorylation) by 60%, but if you add calyculin A, that switch stays on—though a weaker chemical called low-dose okadaic acid doesn’t stop it.

6

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When insulin is present in rat muscle cells, it makes a special pump work harder to move salt in and out of the cells—but if you block certain cleanup enzymes in the cell, the pump doesn’t speed up anymore, which suggests insulin uses those enzymes to turn the pump on.

6

0

78%