Analysis Version
v1
History
Back to Study: Insulin induces translocation of the alpha 2 and b...
causal
Analysis v1
Strong Support

When rats are given insulin, a specific part of a pump in their muscle cells (called the beta 1 subunit) becomes more active and shows up more in the cell’s outer layer, but another similar part (beta 2) stays the same.

6
Pro
0
Against

Evidence from Studies

Supporting (1)

6

Community contributions welcome

6

Insulin induces translocation of the alpha 2 and beta 1 subunits of the Na+/K(+)-ATPase from intracellular compartments to the plasma membrane in mammalian skeletal muscle.

Cohort Study
Animal

The study found that when rats are given insulin, only the beta 1 part of a certain pump moves to the cell surface, while beta 2 stays put — just like the claim said.

Contradicting (0)

0

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No contradicting evidence found

Gold Standard Evidence Needed

According to GRADE and EBM methodology, here is what ideal scientific evidence would look like to definitively prove or disprove this specific claim, ordered from strongest to weakest evidence.

Source Study

Insulin induces translocation of the alpha 2 and beta 1 subunits of the Na+/K(+)-ATPase from intracellular compartments to the plasma membrane in mammalian skeletal muscle.

Score: 6
DOI: 10.1016/s0021-9258(18)42725-1

Similar Assertions

When rats are given insulin, a specific part of a pump in their muscle cells moves from inside the cell to the outer membrane, but another similar part stays where it is.

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94%

When you eat, your body releases insulin, which helps muscle cells pull more potassium from your blood by putting more pumps on their surface—this keeps your muscles working smoothly after meals.

1
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86%

When insulin is present, certain parts of a pump in rat muscle cells move to the surface of the cell—these parts work together like a team that responds to insulin.

6
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86%

When insulin is added to rat muscle cells, it turns down a specific molecular switch (phosphorylation) by 60%, but if you add calyculin A, that switch stays on—though a weaker chemical called low-dose okadaic acid doesn’t stop it.

6
0
80%

When insulin is present in rat muscle cells, it makes a special pump work harder to move salt in and out of the cells—but if you block certain cleanup enzymes in the cell, the pump doesn’t speed up anymore, which suggests insulin uses those enzymes to turn the pump on.

6
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80%