causal
Analysis v1
14
0
In rats, a ketone body made the heart contract more forcefully, as shown by faster pressure changes in arteries.
Scientific Claim
In rats, intraperitoneal administration of racemic sodium 3-hydroxybutyrate increased arterial dP/dt_max by 31.9±11.2% compared to equimolar sodium chloride, indicating enhanced cardiac contractility.
Original Statement
“3-OHB increased the maximal rate of rise of the arterial blood pressure (dP/dtmax) by 31.9±12.9% (Fig. 1D).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
The invasive hemodynamic measurements with controlled interventions support definitive causal language for the specific experimental conditions.
Evidence from Studies
Supporting (1)
14
14
Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility
Randomized Controlled Trial
Animal
2023 Sep 9Contradicting (0)
0
No contradicting evidence found