In rats, a ketone body reduced resistance in blood vessels without changing overall blood pressure.
Scientific Claim
In rats, intraperitoneal administration of racemic sodium 3-hydroxybutyrate (1.32 g/kg) lowered systemic vascular resistance by 30.6±11.2% without significantly affecting mean arterial blood pressure.
Original Statement
“Based on rats with matched recordings of cardiac output and mean arterial blood pressure, we estimate that 3-OHB lowers systemic vascular resistance by 30.6±11.2% (Fig. 1E). The recordings revealed no significant effect of 3-OHB on mean arterial blood pressure, pulse pressure, systolic or diastolic blood pressure (Fig. 1D).”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
definitive
Can make definitive causal claims
Assessment Explanation
The in vivo hemodynamic measurements with controlled interventions support definitive causal language for the specific experimental conditions.
Evidence from Studies
Supporting (1)
Ketone body 3-hydroxybutyrate elevates cardiac output through peripheral vasorelaxation and enhanced cardiac contractility