In rats, a specific part of the genome (RNO10) controls the amount of Actinobacteria bacteria in the mouth, and this is linked to blood pressure levels.
Scientific Claim
The RNO10 genetic locus in rats regulates the abundance of oral Actinobacteria, which is associated with blood pressure regulation.
Original Statement
“the abundance of oral Actinobacteria was upregulated by the BP locus on RNO10 in both sexes”
Evidence Quality Assessment
Claim Status
appropriately stated
Study Design Support
Design supports claim
Appropriate Language Strength
association
Can only show association/correlation
Assessment Explanation
The study demonstrates statistical association between a specific genetic locus and microbiota abundance. The phrase 'upregulated by the BP locus' correctly reflects the correlational nature of the finding without implying direct causation.
More Accurate Statement
“The RNO10 genetic locus in rats is associated with the abundance of oral Actinobacteria, which is associated with blood pressure regulation.”