The Claim
Oral supplementation with half-doses of L-citrulline and L-arginine together produces a greater increase in plasma nitric oxide metabolites and cyclic GMP than full-dose supplementation of either amino acid alone in rats and rabbits.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In rats and rabbits, giving half the usual amount of both L-citrulline and L-arginine together increases plasma nitric oxide metabolites and cyclic GMP more than giving the full amount of either one alone.
See the scientific wording
In rats and rabbits, oral supplementation with L-citrulline and L-arginine at half-dose each produces a greater increase in plasma nitric oxide metabolites (NOx) and cyclic GMP than either amino acid alone at full dose.
When both L-citrulline and L-arginine are taken together, the body converts L-citrulline into more L-arginine in the kidneys, which floods the bloodstream with the raw material needed to make nitric oxide. This extra L-arginine lets blood vessel cells produce more nitric oxide, which then triggers a chain reaction that increases cyclic GMP, leading to wider blood vessels and better blood flow.
What the research says
1 studyGiving rats and rabbits half the usual amount of both L-citrulline and L-arginine together made their bodies produce more nitric oxide-related molecules than giving them the full amount of just one of them alone.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.