The Claim
Oral co-administration of L-citrulline and L-arginine at half-dose each significantly increases blood flow in the central ear artery of rats and rabbits compared to control conditions.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
When rats and rabbits are given a combination of L-citrulline and L-arginine at reduced doses by mouth, blood flow in the central ear artery increases compared to when they are not given these substances.
See the scientific wording
In rats and rabbits, oral co-administration of L-citrulline and L-arginine at half-dose each significantly increases blood flow in the central ear artery compared to control conditions, suggesting acute vasodilatory effects.
When L-citrulline and L-arginine are taken together by mouth, the body converts L-citrulline into more L-arginine, which gives the blood vessels more raw material to make nitric oxide. Nitric oxide tells the muscle around the blood vessels to relax, which opens the vessels wider and lets more blood flow through.
What the research says
1 studyWhen rats and rabbits were given a mix of two amino acids (L-citrulline and L-arginine) at half the usual dose each, their ear blood flow went up quickly — meaning their blood vessels opened wider. This didn’t happen as much when they got just one of the amino acids.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.