The Claim

Supplementation with sacha inchi oil at doses of 0.13–0.39 g/day for eight weeks in rats fed a high-fat diet and fructose-containing water is associated with significantly reduced hepatic triglyceride levels and suppressed mRNA expression of the lipogenic genes ChREBP, ACC1, and FAS.

Source: Sacha inchi oil suppresses hepatic triglyceride synthesis through inhibition of lipogenic gene expression in rats with high-fat and high-fructose intake

What the research says

Supports is higher

Support is ahead, but a single strong opposing study can change this.

Supports
14score
Challenges
0score

These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.

How it works
1 study reviewed
In plain English

In rats fed a high-fat diet with fructose water, daily sacha inchi oil supplementation for eight weeks reduces liver fat and lowers the activity of genes involved in fat production.

See the scientific wording

Supplementation with sacha inchi oil at doses of 0.13–0.39 g/day for eight weeks in rats fed a high-fat diet and fructose-containing water is associated with significantly reduced hepatic triglyceride levels and suppressed mRNA expression of the lipogenic genes ChREBP, ACC1, and FAS, suggesting a potential role in mitigating diet-induced hepatic lipid accumulation.

Why this might work

Omega-3 fatty acids from sacha inchi oil block the activation of a key fat-making switch in the liver, which turns down the production of enzymes that build triglycerides. At the same time, these fatty acids cause the breakdown of another enzyme that assembles triglycerides, leaving less fat stored in the liver.

Verified mechanismbased on 1 study

What the research says

1 study
  1. Study: Sacha inchi oil suppresses hepatic triglyceride synthesis through inhibition of lipogenic gene expression in rats with high-fat and high-fructose intake

    In rats eating a fatty, sugary diet, giving them sacha inchi oil for eight weeks lowered fat buildup in their livers by turning down genes that make new fat — exactly what the claim says.

Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies

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