The Study
Sacha inchi oil suppresses hepatic triglyceride synthesis through inhibition of lipogenic gene expression in rats with high-fat and high-fructose intake
This study gave rats a special oil and saw that their livers made less fat. But it doesn't prove the oil causes less fat in people — it only shows what happened in rats under a very specific diet. Think of it like noticing your pet dog gets less sleepy after eating a new treat — it doesn't mean the treat will make people sleepy.
Analysis score
Maximum 90 for a randomized controlled trial.
Where the score came from
Rats ate a bad diet (fat + sugar water) and got fatty livers. When they got a little bit of oil from sacha inchi nuts every day, their livers stayed much healthier.
Where does this study sit?
Reviews of RCTs (Meta-analyses)
Max 100Randomized Trials
Max 90Reviews of Cohort Studies
Max 85Cohort Studies
Max 72Reviews of Case-Control Studies
Max 63Case-Control Studies
Max 58Cross-Sectional & Case Series
Max 50Expert Opinion
Max 514 / 100
Quality score
Participants are randomly assigned to treatment or control groups, minimizing bias. The gold standard for testing whether an intervention causes an effect.
Key takeaways
Summary
Based on the study abstract and findings.
- 1Yes — if this works in humans, even a tiny daily dose of this oil might help prevent fatty liver caused by sugary and fatty diets.
- 2Rats on bad diet: fatty liver (8% fat).
- 3Rats on bad diet + sacha inchi oil (any dose): near-normal liver (1–2% fat).
- 4Gene activity for making fat dropped in liver.
Score breakdown, methodology, conflicts of interest, evidence analysis & raw study data
Publication
Journal
Functional Food Science - Online ISSN: 2767-3146
Year
2026
Authors
D. Rubi, Arta Farmawati, Sunarti Sunarti
Related Content
Claims (6)
Consuming fructose from high-fructose corn syrup causes the liver to convert it into fat, which builds up in the liver as triglycerides.
In rats fed a high-fat diet with fructose water, daily sacha inchi oil supplementation for eight weeks reduces liver fat and lowers the activity of genes involved in fat production.
In rats fed a high-fat, high-sugar diet, daily supplementation with sacha inchi oil at doses of 0.13–0.39 grams reduces fat buildup in the liver and improves liver tissue structure compared to unsupplemented rats.
In rats eating a diet high in fat and sugar, sacha inchi oil lowers the activity of specific genes involved in fat production—ChREBP, ACC1, and FAS—but does not change the activity of the SREBP-1c gene.
In rats eating a high-fat and high-sugar diet, sacha inchi oil lowers the amount of DGAT2 protein in the liver without changing the gene message that codes for it, showing that the reduction happens after the gene is read.
In rats eating a high-fat, high-sugar diet, adding sacha inchi oil at any dose between 0.13 and 0.39 grams per day reduces fat buildup and gene activity related to fat production in the liver, and the smallest dose works as well as the largest.
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.