The Claim
In rats fed a high-fat and high-fructose diet, supplementation with sacha inchi oil reduces hepatic DGAT2 protein levels without changing DGAT2 mRNA expression, indicating post-transcriptional regulation of DGAT2, the final enzyme in triglyceride synthesis.
What the research says
Supports is higher
Support is ahead, but a single strong opposing study can change this.
These are independent scores, not a percentage. Higher-grade studies count more, so a single strong opposing study can outweigh several weaker ones.
In rats eating a high-fat and high-sugar diet, sacha inchi oil lowers the amount of DGAT2 protein in the liver without changing the gene message that codes for it, showing that the reduction happens after the gene is read.
See the scientific wording
In rats on a high-fat and high-fructose diet, sacha inchi oil supplementation reduces hepatic DGAT2 protein levels without altering DGAT2 mRNA expression, suggesting post-transcriptional regulation of the final enzyme in triglyceride synthesis.
Sacha inchi oil provides fatty acids that reduce the buildup of fat building blocks in the liver. With fewer of these building blocks present, the enzyme that assembles final fat molecules becomes unstable and is broken down by the cell's waste disposal system. This lowers the amount of enzyme available to make fat, even though the gene for the enzyme stays active.
What the research says
1 studySacha inchi oil made the liver produce less of the fat-building enzyme, even though the gene for that enzyme stayed the same — meaning the oil probably made the enzyme break down faster, not stop being made.
Score breakdown, mechanism chain, raw evidence, ideal studies needed & 1 supporting studies
Not medical advice. For informational purposes only. Always consult a qualified healthcare professional before making health decisions.